1. Dr. Randy Cron. Pediatric rheumatology, Cytokine storm expert. Biography. 0
Dr. Randy Cron, MD, explains the critical nature of cytokine storm. He discusses its role in Multisystem Inflammatory Syndrome in Children (MIS-C) after COVID-19.
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2. Multisystem inflammatory syndrome in children. MIS-C. Kawasaki disease. 1
Dr. Randy Cron, MD, explains how a cytokine storm causes Multisystem Inflammatory Syndrome in Children (MIS-C) after COVID-19. MIS-C is a rare but serious post-viral...
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3. Multisystem inflammatory syndrome in children. MIS-C. Susceptibility factors. 2
Dr. Randy Cron, MD, explains the susceptibility factors for multisystem inflammatory syndrome in children (MIS-C). He details the surprising finding that previously healthy children are...
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4. Multisystem inflammatory syndrome in children. MIS-C. Prognosis and recovery. 3
Dr. Randy Cron, MD, explains the prognosis and recovery for children with Multisystem Inflammatory Syndrome (MIS-C). He details the typical hospital course, cardiac outcomes, and...
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5. Cytokine storm treatment. Part 1. Causes: Covid-19. CAR T-cell therapy. 4
Dr. Randy Cron, MD, explains how the COVID-19 pandemic brought this life-threatening immune overreaction into common knowledge. He details the unique characteristics of the COVID-19...
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6. Cytokine storm treatment. Part 2. JAK inhibitors. Corticosteroids. 5
Dr. Randy Cron, MD, explains the role of JAK inhibitors and corticosteroids in treating severe COVID-19. He details how these immunomodulatory therapies work.
Dr. Randy Cron, MD, explains the use of IL-1 and IL-6 inhibitors for treating severe COVID-19. He discusses the timing and sequencing of these biologic...
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8. Cytokine storm treatment. Part 4. ‘Inflammo-stabilization’ strategy. 7
Dr. Randy Cron, MD, explains the innovative 'inflammo-stabilization' treatment strategy. He details how targeting a single key cytokine can restore immune system balance during a...
Dr. Randy Cron, MD, explains the complex terminology and pathophysiology of macrophage activation syndrome (MAS). He details how MAS is a form of secondary hemophagocytic...
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10. Cytokine storm risk in hospitalized patients with fever. Occam's razor (a diagnostic principle). 9
Dr. Randy Cron, MD, explains the diagnostic challenge of identifying cytokine storms in hospitalized patients with fever. He discusses why Occam's razor can be misleading...
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11. Cytokine storm. Genetic susceptibility. Part 1. 10
Dr. Randy Cron, MD, explains the genetic susceptibility to these life-threatening immune overreactions. He details the threshold model where partial genetic defects combine with triggers...
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12. Genomic sequencing and Cytokine storm susceptibility. Part 2. 11
Dr. Randy Cron, MD, explains how genomic sequencing identifies rare heterozygous mutations that increase susceptibility to severe inflammatory responses. He discusses the complex interpretation of...
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13. Future of pediatric rheumatology. Early use of biologics instead of ‘treating to target’. 13
Dr. Randy Cron, MD, explains the future of treatment for children with rheumatic diseases. He discusses the shift from a traditional pyramid approach to an...
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14. Pediatric rheumatic disease treatment. ‘Reverse the pyramid’ when choosing treatment. 14
Dr. Randy Cron, MD, explains the paradigm shift in treating chronic rheumatic diseases in children. He advocates for a "reverse the pyramid" approach, starting with...
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15. Arthritis in children. FAQ. Nutrition in arthritis. Will my child outgrow arthritis? 15
Dr. Randy Cron, MD, explains the role of diet and nutrition in juvenile arthritis. He clarifies common misconceptions about children outgrowing juvenile idiopathic arthritis (JIA)....
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16. Pediatric arthritis FAQ. Can a child with arthritis lead a normal life? 16
Dr. Randy Cron, MD, explains how children with arthritis can lead normal lives. He discusses the shock of a juvenile arthritis diagnosis.
Dr. Randy Cron, MD, explains a dramatic case of a teenage girl with cytophagic histiocytic panniculitis. She developed a life-threatening cytokine storm with multi-organ failure....
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18. Lessons from COVID-19 pandemic. Right and wrong predictions. 18
Dr. Randy Cron, MD, explains the most surprising lessons from the COVID-19 pandemic. He discusses his incorrect prediction about vaccine development and his correct prediction...
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19. Pediatric rheumatology must be better organized. Top expert shares wisdom. 19
Dr. Randy Cron, MD, explains the need for better organization in the subspecialty. He advocates for an early and aggressive treatment approach for rheumatic diseases...
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20. Pediatric rheumatic diseases today vs. 20 years ago. Progress in treatment. Paradigm shifts. 12
Dr. Randy Cron, MD, explains how biologic agents have revolutionized treatment for juvenile idiopathic arthritis. He details the paradigm shift in care over the last...
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