HPV vaccination is recommended before teenagers reach a puberty level. Young adults can also be vaccinated against HPV, Human Papilloma Virus. Dr. Anton Titov, MD. There is the generation of the first people who were vaccinated against HPV. Dr. Anton Titov, MD. How will that change screening strategy for cervical cancer? Dr. Jack Cuzick, PhD. There were a number of things that will actually change. The original HPV vaccination was focused on the people who will have highest benefit. Because the HPV vaccine was expensive. HPV vaccination focused on the girls before they become sexually active. The goal was to avoid HPV infection before vaccination. Now there is a new 9-valent HPV vaccine against nine HPV types. There is an increasing interest in developing policies to expand HPV vaccination. So we can screen for HPV infection adults. We can vaccinate against HPV up to 45 or 50 years of age. So you would screen out any cervical cancer associated with HPV infection.But then you would vaccinate against HPV to prevent against all future HPV infections. So these cervical cancer screening and HPV vaccination in combination may lead to a rapid reduction in cervix cancer. Dr. Jack Cuzick, PhD. This could be better than just vaccinating teenagers in early adolescence. We can screen the rest of the population for HPV infection. The vaccination against HPV in early adolescence will be highly effective. But it will be 20 to 30 to 40 years before vaccinated teenagers reach the age in which cervix cancer is common. This is one of the things we are interested is this clinical trial called FASTER. It is designed to not only get cervical cancer protection in early group of vaccinated people. Dr. Jack Cuzick, PhD. But we have to accelerate benefits of HPV vaccination. Then we can actually start seeing more rapid reductions in cervical cancer more quickly. That means we should vaccinate people against HPV up to the age of 50. Dr. Anton Titov, MD. Women over age 25 would need to be screened for cervical cancer. They should be vaccinated against HPV at the same time.
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