“In the next few years we will do full molecular profiling of all colon cancer patients”. “We will monitor colon cancer molecular profile changes in real time. We can identify the mechanism of resistance to chemotherapy. We can predict progression of colon cancer.” “Metastatic colon cancer will be not one disease anymore. It may be 50 diseases, 40 diseases, 100 diseases. Cancer is defined by the molecular profiling of colon cancer tumor.” “In 10 years, I hope we will have cured all colon cancer patients.”

Future of personalized medicine in Colorectal Cancer. Precision medicine will result in colon cancer treatment and cure. Full molecular profiling of the colon cancer patients and full gene profiling of colorectal cancer tumors for each patient. Leading German-American colorectal cancer oncologist discusses trends in colon cancer treatment. Predictive medicine to treat colon cancer tumor before it starts growing again. Real time genetic profile of colon cancer during chemotherapy treatment. Detailed molecular classification of colon cancer into 50 or 100 different colon cancers based on genetic mutations in many genes (not just KRAS, NRAS, BRAF, MSI, PTEN). Targeted chemotherapy and gene therapy to attack colon cancer stem cells. In 10 years all colon cancer patients will be cured. Personalized medicine prevention of colon cancer based on genetic information of patient and family. Advanced stage 4 colon cancer treatment by precision medicine and targeted chemotherapy. 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It's important to talk about what will the future bring in treatment of colon cancer and rectal cancer. You are very positive about very exciting treatments of colon cancer. Success is facilitated by personalized medicine, precision medicine. There is a specific molecular testing and diagnosis of patients with colon cancer. You are a leader in colorectal cancer research and treatment. What do you see as the most important new diagnostic and treatment options in the next 10 years for patients with colorectal cancer? Maybe you could give some specific examples of colon cancer treatment advances. Please add to what you've already talked about. Dr. Heinz-Josef Lenz, MD (Colorectal Cancer Expert, California). I don't know what happen in 10 years. But I will tell you what will happen in the next couple of years. I think it happens already in very select clinics. We will do full molecular profiling of the colon cancer patients. Extensive molecular profiles of colon cancer tumors will be done. But they will sometimes make it very difficult for us to understand. What all the genetic profiling results really mean? But molecular tumor profile allows us now to select the best treatment options for colorectal cancer patients. We will monitor colon cancer molecular profile changes in real time. We can identify the mechanism of resistance to chemotherapy. we can predict risks of progression of colon cancer. We will know before the colon cancer tumor starts growing again. We will see into the future what will happen with the tumor. This will allow us to interfere with the treatment before colon cancer progression is visible on a CT scan. That's the first future advance in colon cancer treatment. The second advance in colon cancer treatment is this. With the molecular classification of colon cancer, we will develop treatment options for more patients. Precision medicine treatment defined by the unique patient and tumor profile. Today, we have only KRAS molecular tumor marker. Tomorrow we will have many molecular tumor profile factors. They will point very clearly to specific treatments with high efficacy and low toxicity. Dr. Heinz-Josef Lenz, MD (Colorectal Cancer Expert, California). Colon cancer and metastatic colon cancer will be not one disease anymore. It may be 50 diseases, 40 diseases, 100 diseases. Each variant of cancer will be defined by the molecular profiling of colon cancer tumor. With this approach, the goal has to be to cure more and more patients. I think in the future we will have very specific new medications that target colon cancer stem cells. Cancer stem cells is the ultimate reason for failure of all our treatments of metastatic colon cancer. Colon cancer stem cells cannot be treated or killed by the classical chemotherapy treatments. Cancer stem cells cannot be eliminated even by the new targeted medications that we have now. Dr. Heinz-Josef Lenz, MD (Colorectal Cancer Expert, California). We really need to differentiate colon cancer stem cells from simple tumor cells. Then we can kill differentiated cancer stem cells with chemotherapy. In 10 years, I hope we will have cured all colon cancer patients. We will develop very molecular-specific prevention strategies of colorectal cancer. That will prevent colon cancer in the future. Colon cancer prevention strategies should be based on our understanding of molecular biology of colon cancer tumor cells. Colon cancer prevention methods will be eating broccoli and consuming more fiber. It will be very specific family intervention in very specific high-risk patients for colon cancer development. To prevent colon cancer effectively, we will know that certain high-risk people will need to use this medication or that medication in the future. Dr. Anton Titov, MD. Well, this is a very exciting conversation. Professor Lenz, thank you very much for sharing your enthusiasm for your research achievements. Thank you for sharing insights from your clinical work in colorectal cancer. Thank you very much for this conversation! We are looking forward to returning to the conversation in the future. Dr. Heinz-Josef Lenz, MD (Colorectal Cancer Expert, California). Absolutely. Thank you so much! The future of precision medicine in colorectal cancer is now. Metastatic stage 4 colon patients will be cured with molecular medicine advances.