TAS-102 (Lonsurf) in advanced colon cancer. 5-Fluorouracil is still effective chemotherapy in colorectal cancer. 2

TAS-102 (Lonsurf) in advanced colon cancer. 5-Fluorouracil is still effective chemotherapy in colorectal cancer. 2

TAS-102 (Lonsurf) in advanced colon cancer. 5-Fluorouracil is still effective chemotherapy in colorectal cancer. 2

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TAS-102 is new member of 5-Fluorouracil and Methotrexate family. It has been used successfully in colorectal cancer treatment for 50 years. “I think even today 5-Fluorouracil (5-FU) is the most effective chemotherapy medication in colon cancer.” “But TAS-102 can reduce tumors even when 5-FU does not work anymore.”


TAS-102 (Lonsurf) in advanced colon cancer treatment. TAS-102 (Lonsurf) targets the fluoropyrimidine pathway in refractory colorectal cancer. Leading German-American colorectal cancer oncologist discusses new chemotherapy TAS-102 (Lonsurf) in advanced colon cancer treatment. 5-Fluorouracil and Methotrexate are a backbone of colorectal cancer chemotherapy for 50 years. 5-FU is still very effective chemotherapy for colon cancer. Even today 5-Fluorouracil is the most effective chemotherapy medication in colon cancer. 5 Fluorouracil (5-FU) is a very critical pathway for survival of normal and cancer cells. TAS-102 (Lonsurf) for advanced stage 4 colon cancer treatment is approved in Japan. It will be approved in Europe. Colorectal cancer new targeted chemotherapy options. Refractory stage 4 colon cancer treatment by TAS-102 (Lonsurf). Medical second opinion confirms colorectal cancer diagnosis with molecular profile of colon cancer tumor. Medical second opinion also confirms colon cancer cure is possible in metastatic colon cancer. Best precision medicine treatment by TAS-102 (Lonsurf)for refractory stage 4 colon cancer with metastatic lesions. Medical second opinion helps to select a personalized medicine targeted TAS-102 (Lonsurf)treatment for stage 4 refractory colorectal cancer with liver or lung metastases. Get medical second opinion on advanced colorectal cancer. Be confident that your precision medicine treatment is the best. Best colorectal cancer treatment by new fluoropyrimidine pathway inhibitors TAS-102 (Lonsurf). Video interview with leading expert in metastatic colorectal cancer treatment from California. TAS-102 (Lonsurf) in advanced colon cancer treatment. Colon cancer 5-Fluorouracil therapy. Metastatic stage 4 colon cancer chemotherapy choice. Dr. Anton Titov, MD. Classical colon cancer chemotherapy medications, 5-Fluorouracil (5-FU) and Methotrexate have been used for over 50 years. 5-Fluorouracil and Methotrexate act on thymidylate synthase. This is a very important enzyme in colon cancer cell growth. Thymidylate synthase is an enzyme that has been important historically for the cancer treatment. This includes colon cancer and rectal cancer treatment. Chemotherapy medications that act on thymidylate synthase are being discovered. What are the new advanced stage 4 colon cancer treatments? Dr. Heinz-Josef Lenz, MD (Colorectal Cancer Expert, California). Yeah, I think it's very interesting that you bring that up. Because I think even today 5-Fluorouracil is the most effective chemotherapy medication in colon cancer. It is true even with all the new targeted medications to treat metastatic stage 4 colorectal cancer. I think 5-Fluorouracil (5-FU) will not go away. Because I think initially we were a little bit naive. We thought that new colon cancer treatment medications, new antibodies, would replace our classic cytotoxic treatments. This was as 5 Fluorouracil (5-FU). But it didn't happen. We added the new targeted chemotherapy medications onto our chemotherapeutic backbone of advanced colon cancer therapy. 5-FU is a very important pathway in cancer cell growth. 5 Fluorouracil (5-FU) is a very critical pathway for survival of normal and cancer cells. Dr. Heinz-Josef Lenz, MD (Colorectal Cancer Expert, California). Targeting thymidylate synthase pathway provides a particular benefit for fast-growing cells. They are more sensitive to inhibition of thymidylate synthase. This is key for DNA synthesis. 5-FU is now being combined with either irinotecan or oxaliplatin. It is the backbone of metastatic stage 4 colon cancer chemotherapy protocols. We call these colon cancer treatment protocols FOLFIRI or FOLFOX. But the pathway of fluoropyrimidines is very important. There is the new advanced colon cancer medication called TAS-102. TAS-102 is also targeting the fluoropyrimidine pathway. It targets this molecular cancer pathway in a slightly different method. We know that TAS-102 (Lonsurf) inhibits this pathway. But TAS-102 can work even when 5-FU does not work anymore. TAS 102 (Lonsurf) will be approved at the end of the year in the US. Dr. Heinz-Josef Lenz, MD (Colorectal Cancer Expert, California). TAS-102 (Lonsurf) for advanced stage 4 colon cancer treatment is already approved in Japan. I'm sure that Europe will follow very closely with approval of TAS-102 (Lonsurf). I think classical cytotoxic colon cancer medications were forgotten a little bit. The major focus of colon cancer therapy was on targeted treatments. But classic colon cancer treatment medications remain the most effective part of our combinations. I think we are in need of more cytotoxic medications. Because classic chemotherapy gives us a lot of tumor shrinkage when we need it. I think in the future treatment of colon cancer we will select first the backbone of the chemotherapy. We will use molecular profiling of colon cancer tumor. We will target stage 4 colon cancer treatment based on genetic profile of the tumor. Then we will also choose the best targeted colon cancer treatment. we will use it with a cytotoxic chemotherapy protocol. TAS-102 (Lonsurf) and 5-Fluorouracil (5-FU) in advanced refractory metastatic colon cancer treatment. 5-Fluorouracil, methotrexate, is effective chemotherapy.

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