How to break silos in medicine? Leading lung expert. In era of precision medicine every patient must be evaluated by a multidisciplinary team of top-notch experts. This is the only way to ensure unbiased, correct, precise diagnosis and best treatment for each patient. Leading intensive care and heart failure expert illustrates. Is there anything else you'd like to discuss? Dr. Anton Titov, MD. Is there any topic that you would like to expand upon? Dr. Anton Titov, MD. The biggest issue about my observations in medicine is this. Dr. Aaron Waxman, MD. We touched on that topic earlier. It is the whole silo approach to medicine today. Narrow tubular vision is probably one of the biggest limits to innovation in medicine. One of the wonderful things about here is the sense of a multidisciplinary collaborative approach. we focus on pulmonary arterial hypertension and heart failure. We are setting up these multidisciplinary medical centers. Dr. Aaron Waxman, MD. I was asked to develop the center for pulmonary heart disease. The concept is that we'd bring in surgeons and we'd bring in internists and we bring in radiologists. We collaborate with all specialities who purely have interest in the area of lung disease. This is what we are focusing on. It is pulmonary arterial hypertension, it is right-sided heart failure. Within our center for pulmonary heart disease we have subsets of interested parties. It includes interventional cardiologists, pediatric cardiologists, pulmonologists, intensive medical care experts, pulmonary vascular disease-focused physicians, surgeons. Dr. Aaron Waxman, MD. Surgeons focus on both thoracic and cardiac disease. Everybody has a common overlap at some point. Dr. Anton Titov, MD. You bring all these experts into a room together. You start talking about topics of pulmonary heart disease. Then you come up with ideas of novel approaches to treatment of pulmonary arterial hypertension and heart failure. One treatment method that came out of that is this. We developed a method to do a percutaneous Potts shunt. It is used to treat pulmonary hypertension. Dr. Aaron Waxman, MD. We took several patients who had advanced pulmonary arterial hypertension. These patients were treated to the limits of any treatment option. There was nothing more we could offer these patients with advanced pulmonary arterial hypertension. We could only proceed to lung transplant. But lung transplant for pulmonary hypertension is a complicated process. We worked with our colleagues at Children's Hospital. Dr. Aaron Waxman, MD. We developed a treatment method, where we could go take these patients in the catheterization lab. We could create a bridge from the aorta into the left main pulmonary artery percutaneously. Dr. Aaron Waxman, MD. We place a stent across that vascular bridge. We create a variable shunt that essentially worked as a blow-off valve. This was done without doing an atrial septostomy. By doing it in the aorta to the left main pulmonary artery, you left the upper half of the body with normal oxygenation. And the lower half of the body had hypoxia. The result of that was obviously the kidneys kick in. A patient’s kidney started to produce more red cells. But it wasn't a problem. It did help in the sense that it created a bridge that we could keep working on these patients and give them time to get transplanted. There is still lots of opportunity for improving something like that. But it is an example of how, if you get rid of the silos in medicine, you let people start interacting together and thinking freely. Dr. Aaron Waxman, MD. Then you come up with approaches that people wouldn't have thought of on their own. This is very important, clearly. But also from a patient's perspective it is important. Another aspect of silos is something that is probably structurally also important. The way that healthcare is set up, at least today, it is very hard to get rid of the silos. Dr. Aaron Waxman, MD. This is the silo of any single medical institution or a hospital. Because when a patient walks into the hospital, that hospital says this. "Okay, we will treat you, we are the best for you”. Often the larger hospitals acquire physician group practices. Their referral patterns become fixed. It sends all patients who walk into a physician's office on a certain path, which may be excellent, but may not be an optimal path for that patient. As a patient, you want to be assessed by a multidisciplinary team. Dr. Aaron Waxman, MD. I have never had obviously a bad disease. But I have been a patient in a hospital for minor stuff. But I would want a place that could think outside the box. Especially if I had a rare disease or a difficult disease. I'd be wanting someone to think about, what else can I do here to try to improve the quality of life for that person? Dr. Anton Titov, MD. It may not mean that I'm going to change survival dramatically. But at least improve upon the medical problem. Because the truth is in medicine, and I'm not talking about internal medicine, we rarely cure things. I mean, sure, we cure infections and we cure some cancers. But most disease - we manage, long term. Dr. Aaron Waxman, MD. We don’t cure many diseases. The better we learn how to manage with a goal towards finding a cure, the better off that patient's going to be. Dr. Anton Titov, MD. You get into a place like here, where we have this multidisciplinary, open minded, out-of-the-box thinking processes going on. We serve a great purpose. Worldwide also, modern technology allows us to go beyond any single institution and look at what's available. We know where the experts are located. Dr. Aaron Waxman, MD. We can transfer valuable information to them without perhaps even traveling. It is interesting, because, obviously, with the internet now patients become often their own best advocates. Patients will find the options that are best for their treatment. As a result our dyspnea program is an example. Dr. Aaron Waxman, MD. We have had patients on their own find us and come from all over the world. I would say now. Pretty much every month we are seeing someone who has come a long distance to get an answer as to why they are short of breath. Airline travel is not that expensive, of course, sometimes treatments are expensive. But compared to missed diagnosis and wasted money, the symptoms and the aggravation of the wrong treatment. That certainly is a much better solution. Getting an answer is usually very important to the patient. Dr. Aaron Waxman, MD. Even if you can't make them better, they want to know "what's wrong with me? Dr. Anton Titov, MD." That is very important, getting the right diagnosis, the precise and complete diagnosis. Dr. Waxman, thank you very much for this very interesting conversation about lung disease and heart disease and lung vasculature. We hope to see your continued research and stem-cell research. We hope to come back to you with more questions in the future. Thank you very much! Dr. Aaron Waxman, MD. Thank you, it was fun!