Hello from Milano, We are with Dr. Pier Mannuccio Mannucci, who is a world-renowned expert in the diagnosis and treatment of blood disorders, in particular, blood clots and bleeding. Professor Mannucci is also an expert on air pollution, nutrition, and the overuse of medications. We are going to discuss today's advances in the treatment of bleeding disorders, such as hemophilia and von Willibrand disease. We will talk about the genetics of blood clot formation and its association with not-yet-diagnosed, hidden, or clinical-stage cancer. We discuss what is precision nutrition in the era of precision medicine. We will also talk about air pollution and heart disease. Last but not least, we will discuss what can be done to reduce polypharmacy in elderly patients - prescribing too many medications that, together with end up hurting the patient.

Let me give you a brief overview of the professional career of Professor Pier Mannuccio Mannucci. Dr. Pier Mannuccio Mannucci is an emeritus Professor of Internal Medicine at the University of Milan. He is a former Chairman of the Department of Internal Medicine and Dermatology, University of Milan. He was also a Director of Hemophilia and Thrombosis Center at the University of Milan. Dr. Pier Mannuccio Mannucci was also a Visiting Professor at Harvard Medical School in Boston. Dr. Pier Mannuccio Mannucci obtained his MD from the University of Milan in Italy. He did a fellowship in Blood Coagulation research at the University of Oxford in the UK. Clinical and research interests of Dr. Pier Mannuccio Mannucci include diagnosis and treatment of bleeding and coagulation disorders, such as hemophilia, von Willibrand disease, thrombophilia, genetic causes of blood clot formation and bleeding. Dr. Pier Mannuccio Mannucci has done important research on indoor and outdoor air pollution and its effects on heart and lung disease. He also studied the use of use of medications in elderly patients.

Dr. Pier Mannuccio Mannucci held many high scientific and editorial positions in his career. He was President of Italian and International Societies for Haemostasis and Thrombosis, President of, Italian Society for Internal Medicine. Dr. Pier Mannuccio Mannucci was Editor-in-Chief of Journal of Thrombosis and Hemostasis and Journal of European Journal of Internal Medicine. He held editorial positions in dozens of other medical journals. Dr. Pier Mannuccio Mannucci has authored and co-authored over 1300 peer-reviewed publications in international medical journals. He presented numerous talks at international conferences on hematology research and treatment. Dr. Pier Mannuccio Mannucci, hello and welcome!

Thank you for the nice presentation. I am available to answer your questions. You presented them very adequately and so I'm here, at your disposal.

Thank you.