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Breast Cancer.
Human Touch.

Dr. Giuseppe Curigliano
ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ื’ืœื™ืื ื•. ืžื•ืžื—ื” ืœื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“. ืงื•ืจื•ืช ื—ื™ื™ื. 0
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1. ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ื’ืœื™ืื ื•. ืžื•ืžื—ื” ืœื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“. ืงื•ืจื•ืช ื—ื™ื™ื. 0

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“ ื•ื‘ืคื™ืชื•ื— ืชืจื•ืคื•ืช ื—ื“ืฉื•ืช, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ืขืœ ื”ื—ื™ื“ื•ืฉื™ื ื”ืื—ืจื•ื ื™ื ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ืฉื“ HER2-ื—ื™ื•ื‘ื™, HER2-ืฉืœื™ืœื™ ื•ืฉืœื™ืœื™ ืžืฉื•ืœืฉ. ื”ื•ื ืžืคืจื˜...

ื˜ื™ืคื•ืœ ืžืžื•ืงื“ ื‘ืกืจื˜ืŸ ื”ืฉื“. ืžื”ื ื”ื™ืขื“ื™ื ื”ืžื•ืœืงื•ืœืจื™ื™ื ืฉืœ ื”ืชืจื•ืคื•ืช? 1
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2. ื˜ื™ืคื•ืœ ืžืžื•ืงื“ ื‘ืกืจื˜ืŸ ื”ืฉื“. ืžื”ื ื”ื™ืขื“ื™ื ื”ืžื•ืœืงื•ืœืจื™ื™ื ืฉืœ ื”ืชืจื•ืคื•ืช? 1

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“ ื•ื‘ืคื™ืชื•ื— ืชืจื•ืคื•ืช ื—ื“ืฉื•ืช, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ื›ื™ืฆื“ ื˜ื™ืคื•ืœื™ื ืžืžื•ืงื“ื™ื ืžื—ื•ืœืœื™ื ืžื”ืคื›ื” ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“ ื‘ืืžืฆืขื•ืช ืคื’ื™ืขื” ื‘ืžื˜ืจื•ืช ืžื•ืœืงื•ืœืจื™ื•ืช ืกืคืฆื™ืคื™ื•ืช....

ืจืคื•ืื” ืžื•ืชืืžืช ืื™ืฉื™ืช ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“. ืชืจื•ืคื•ืช ืžืžื•ืงื“ื•ืช ืื• ื›ื™ืžื•ืชืจืคื™ื”? 2
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3. ืจืคื•ืื” ืžื•ืชืืžืช ืื™ืฉื™ืช ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“. ืชืจื•ืคื•ืช ืžืžื•ืงื“ื•ืช ืื• ื›ื™ืžื•ืชืจืคื™ื”? 2

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ืจืคื•ืืช ื“ื™ื•ืง ืœืกืจื˜ืŸ ื”ืฉื“, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ื›ื™ืฆื“ ื˜ื™ืคื•ืœื™ื ืžืžื•ืงื“ื™ื ื—ื“ืฉื™ื ื•ื‘ื“ื™ืงื•ืช ื’ื ื•ืžื™ื•ืช ืžืฉื ื™ื ืืช ื”ื˜ื™ืคื•ืœ ื‘ืฉืœื‘ ื”ืžื•ืงื“ื. ื”ื•ื ืžืคืจื˜ ืืช...

ืกืจื˜ืŸ ืฉื“ ื—ื™ื•ื‘ื™ ืœื”ื•ืจืžื•ื ื™ื, ืฉืœื™ืœื™ ืœ-HER2 ืฆื™ืžื•ื“ื™ื ืฉืœ ื ื•ื’ื“ืŸ-ืชืจื•ืคื” (Antibody-drug conjugates) 3
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4. ืกืจื˜ืŸ ืฉื“ ื—ื™ื•ื‘ื™ ืœื”ื•ืจืžื•ื ื™ื, ืฉืœื™ืœื™ ืœ-HER2 ืฆื™ืžื•ื“ื™ื ืฉืœ ื ื•ื’ื“ืŸ-ืชืจื•ืคื” (Antibody-drug conjugates) 3

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“ ื•ื‘ื’ื™ืœื•ื™ ืชืจื•ืคื•ืช ืžื•ืงื“ื, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ืขืœ ื”ื—ื™ื“ื•ืฉื™ื ื”ืื—ืจื•ื ื™ื ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ืฉื“ ื—ื™ื•ื‘ื™ ืœืงื•ืœื˜ื ื™ื ื”ื•ืจืžื•ื ืœื™ื™ื ื•ืฉืœื™ืœื™ ืœ-HER2. ื”ื•ื ืžืคืจื˜...

ืกืจื˜ืŸ ืฉื“ ื—ื™ื•ื‘ื™ ืœ-HER2 - ื˜ื™ืคื•ืœ. ื˜ื•ืงืื˜ื™ื ื™ื‘. ื˜ืจืกื˜ื•ื–ื•ืžื‘ ื“ืจื•ืงืกื˜ืงืืŸ. 4
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5. ืกืจื˜ืŸ ืฉื“ ื—ื™ื•ื‘ื™ ืœ-HER2 - ื˜ื™ืคื•ืœ. ื˜ื•ืงืื˜ื™ื ื™ื‘. ื˜ืจืกื˜ื•ื–ื•ืžื‘ ื“ืจื•ืงืกื˜ืงืืŸ. 4

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ืฉื“ HER2-ื—ื™ื•ื‘ื™, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ืขืœ ื”ื—ื™ื“ื•ืฉื™ื ื”ืื—ืจื•ื ื™ื ื‘ื˜ื™ืคื•ืœ ื‘ืชืช-ืกื•ื’ ืื’ืจืกื™ื‘ื™ ื–ื” ืฉืœ ืกืจื˜ืŸ ื”ืฉื“. ื”ื•ื ืžืคืจื˜ ืืช ื”ืชืคืงื™ื“...

ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ืฉื“ ืฉืœื™ืœื™ ืžืฉื•ืœืฉ. ื”ืชื•ื•ื™ื•ืช ืœื˜ื™ืคื•ืœ ื ื™ืื•-ืื“ื’'ื•ื‘ื ื˜ื™. 5
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6. ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ืฉื“ ืฉืœื™ืœื™ ืžืฉื•ืœืฉ. ื”ืชื•ื•ื™ื•ืช ืœื˜ื™ืคื•ืœ ื ื™ืื•-ืื“ื’'ื•ื‘ื ื˜ื™. 5

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ื’ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ืขืœ ื”ื—ื™ื“ื•ืฉื™ื ื”ืื—ืจื•ื ื™ื ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ืฉื“ ืฉืœื™ืœื™ ืžืฉื•ืœืฉ, ื›ื•ืœืœ ืื™ืžื•ื ื•ืชืจืคื™ื”, ืžืฆืžื™ื“ื™ ื ื•ื’ื“ืŸ-ืชืจื•ืคื” ื•ืžืขื›ื‘ื™ PARP. ื”ื•ื ืžืคืจื˜...

ืื™ืžื•ื ื•ืชืจืคื™ื” ืœืกืจื˜ืŸ ื”ืฉื“. ืกืจื˜ืŸ ืฉื“ ืฉืœื™ืœื™ ืœืฉืœื•ืฉืช ื”ืงื•ืœื˜ื ื™ื. ืžืฆืžื™ื“ื™ ื ื•ื’ื“ืŸ-ืชืจื•ืคื”. 6
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7. ืื™ืžื•ื ื•ืชืจืคื™ื” ืœืกืจื˜ืŸ ื”ืฉื“. ืกืจื˜ืŸ ืฉื“ ืฉืœื™ืœื™ ืœืฉืœื•ืฉืช ื”ืงื•ืœื˜ื ื™ื. ืžืฆืžื™ื“ื™ ื ื•ื’ื“ืŸ-ืชืจื•ืคื”. 6

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ืื™ืžื•ื ื•ืชืจืคื™ื” ืœืกืจื˜ืŸ ื”ืฉื“, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ื›ื™ืฆื“ ื‘ื—ื™ืจืช ืžื˜ื•ืคืœื•ืช ืขืœ ื‘ืกื™ืก ื”ืคืจื•ืคื™ืœ ื”ื—ื™ืกื•ื ื™ ืฉืœ ื”ื’ื™ื“ื•ืœ ื”ื™ื ืงืจื™ื˜ื™ืช ืœื”ืฆืœื—ื”. ื”ื•ื ืžืคืจื˜ ืืช...

ืชื•ืคืขื•ืช ืœื•ื•ืื™ ืฉืœ ืื™ืžื•ื ื•ืชืจืคื™ื” ื‘ื—ื•ืœื•ืช ืกืจื˜ืŸ ื”ืฉื“. 7
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8. ืชื•ืคืขื•ืช ืœื•ื•ืื™ ืฉืœ ืื™ืžื•ื ื•ืชืจืคื™ื” ื‘ื—ื•ืœื•ืช ืกืจื˜ืŸ ื”ืฉื“. 7

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ืื™ืžื•ื ื•ืชืจืคื™ื” ืœืกืจื˜ืŸ ื”ืฉื“, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ืืช ืชื•ืคืขื•ืช ื”ืœื•ื•ืื™ ื”ื ืคื•ืฆื•ืช ื‘ื™ื•ืชืจ ืฉืœ ืžืขื›ื‘ื™ ื ืงื•ื“ื•ืช ื‘ืงืจื” ื—ื™ืกื•ื ื™ืช, ื›ื•ืœืœ ืคืจื™ื—ื” ืขื•ืจื™ืช, ื“ืœืงืช ื›ื‘ื“...

ืขืชื™ื“ ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“. ื”ืคื—ืชืช ืขื•ืฆืžืช ื”ื˜ื™ืคื•ืœ. ืจื™ืคื•ื™ ืกืจื˜ืŸ ื’ืจื•ืจืชื™? 8
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9. ืขืชื™ื“ ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“. ื”ืคื—ืชืช ืขื•ืฆืžืช ื”ื˜ื™ืคื•ืœ. ืจื™ืคื•ื™ ืกืจื˜ืŸ ื’ืจื•ืจืชื™? 8

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ื˜ื™ืคื•ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ืืช ืขืชื™ื“ ื”ื˜ื™ืคื•ืœ, ืชื•ืš ื”ืชืžืงื“ื•ืช ื‘ืฉืœื•ืฉื” ืžื•ืฉื’ื™ื ืžืจื›ื–ื™ื™ื: ื”ืคื—ืชืช ืขื•ืฆืžืช ื”ื˜ื™ืคื•ืœ ื‘ื—ื•ืœื™ื ื‘ืกื™ื›ื•ืŸ ื ืžื•ืš, ืคื™ืชื•ื—...

ืกืจื˜ืŸ ืฉื“ ืฉืœื™ืœื™ ืžืฉื•ืœืฉ ื’ืจื•ืจืชื™. ื”ื™ืฉืจื“ื•ืช ืืจื•ื›ืช ื˜ื•ื•ื—. ืžืงืจื” ืงืœื™ื ื™. 9
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10. ืกืจื˜ืŸ ืฉื“ ืฉืœื™ืœื™ ืžืฉื•ืœืฉ ื’ืจื•ืจืชื™. ื”ื™ืฉืจื“ื•ืช ืืจื•ื›ืช ื˜ื•ื•ื—. ืžืงืจื” ืงืœื™ื ื™. 9

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“ ื•ืื™ืžื•ื ื•-ืื•ื ืงื•ืœื•ื’ื™ื”, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ื›ื™ืฆื“ ืžื˜ื•ืคืœืช ืขื ืกืจื˜ืŸ ืฉื“ ืฉืœื™ืœื™ ืžืฉื•ืœืฉ ื’ืจื•ืจืชื™ ื”ืฉื™ื’ื” ื”ื™ืฉืจื“ื•ืช ืืจื•ื›ืช ื˜ื•ื•ื— ืฉืœ ื›ืžืขื˜ ืขืฉื•ืจ...

ืืชื” ื—ื™ื™ื‘ ืœื”ืขื ื™ืง ืœืžื˜ื•ืคืœืช ืžื’ืข ืื ื•ืฉื™. ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ืœืกืจื˜ืŸ ื”ืฉื“ ืžืฉืชืฃ ื‘ืชื•ื‘ื ื•ืช. 10
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11. ืืชื” ื—ื™ื™ื‘ ืœื”ืขื ื™ืง ืœืžื˜ื•ืคืœืช ืžื’ืข ืื ื•ืฉื™. ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ืœืกืจื˜ืŸ ื”ืฉื“ ืžืฉืชืฃ ื‘ืชื•ื‘ื ื•ืช. 10

ืžื•ืžื—ื” ืžื•ื‘ื™ืœ ื‘ืกืจื˜ืŸ ื”ืฉื“, ื“"ืจ ื’'ื•ื–ืคื” ืงื•ืจื™ื’ืœื™ืื ื•, MD, ืžืกื‘ื™ืจ ืืช ื”ื—ืฉื™ื‘ื•ืช ื”ืงืจื™ื˜ื™ืช ืฉืœ ื”ืžื’ืข ื”ืื ื•ืฉื™ ื‘ื˜ื™ืคื•ืœ ื‘ื—ื•ืœื”, ื•ืžื“ื’ื™ืฉ ื›ื™ ื—ืžืœื” ื•ืชืฉื•ืžืช ืœื‘ ืื™ืฉื™ืช ื”ืŸ ื—ื™ื•ื ื™ื•ืช...

ืฉืคืจ ืืช ืชื•ื›ื ื™ืช ื”ื˜ื™ืคื•ืœ ืฉืœืš ืขื ืคืื ืœ ืฉืœ ืจื•ืคืื™ื ืžื•ื‘ื™ืœื™ื ืฉืžืชืื™ืžื™ื ื‘ื“ื™ื•ืง ืœืžืงืจื” ืฉืœืš.

ืฉืคืจ ืืช ืชื•ื›ื ื™ืช ื”ื˜ื™ืคื•ืœ ืฉืœืš ืขื ืคืื ืœ ืฉืœ ืจื•ืคืื™ื ืžื•ื‘ื™ืœื™ื ืฉืžืชืื™ืžื™ื ื‘ื“ื™ื•ืง ืœืžืงืจื” ืฉืœืš.

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