Statins is another medication that is well known. Dr. Anton Titov, MD. New effects of statins seem to be discovered. Initially statins were developed for lowering of cholesterol at certain doses. There is some data from research laboratories. Statins might also have a preventive effect on certain cancers. There is maybe some clinical data for this effect of statins. It is being published. Dr. Anton Titov, MD. Perhaps statins also have a protective cardiovascular effects at lower dosages. This would mean that their action may not be so dependent on cholesterol-lowering per se. Statins could have an effect on the internal wall of blood vessels. Dr. Anton Titov, MD. What do you think about the potential for statins in chemoprevention of cancer? Dr. Jack Cuzick, PhD. Statins perhaps not only prevent cardiovascular disease, but statins might also prevent certain cancers. The evidence for statins and cancer is really quite mixed. There are some clinical trials showing very clear preventive effect of statins on cancer. Other clinical trials have equally good quality. They show no impact on cancer. Dr. Jack Cuzick, PhD. A few clinical trials even showed a slight increase in cancer. In fact, one of the original concerns with statins is that they would actually increase cancer rates. That seems to not be true. Statins are not likely to increase cancer risks. But equally it is pretty clear so far that there is no clear evidence for a reduction in cancer by statins. Dr. Jack Cuzick, PhD. Maybe there are some types of cancer that statins have an impact on. But we haven’t discovered that with any certainty yet. The overall evidence suggests a minimal impact of statins on cancer.
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