Liver transplantation from animals: hope and challenges explained by top expert in liver disease. How close we are to reliable transplantation of liver from animals? How to overcome challenges to liver xenotransplantation?
Video interview with top expert in liver diseases about current state of liver transplantation from animals.
Liver transplantation from animals: hope and challenges explained. Video interview with top expert in liver diseases (Harvard Medical School) Dr. Simon Robson: does liver xenotransplantation research for 20 years. How close we are to transplant animal organs into humans? There is a progress in farming animal organs for human transplantation. Problems are organ rejection and transfer of animal infections. Liver transplantation from animals does not work very well today. Organ rejection happens by complement activation. Modification of pig liver by genetic engineering to prevent rejection is possible. Enzyme CD39 plays important role in transplantation. It removes ATP. Pig liver transplantation is possible as temporary measure until human donor liver is found. Second opinion helps to make sure diagnosis of liver failure is correct and complete. Second opinion in liver failure also helps to choose the best treatment to delay need for transplant. Animal viral infections are Reston ebola type virus and pig cytomegalovirus. They can potentially transmit to human organ recipients. Advantages of xenotransplantation are ready source of organs from “farmed animals”. Disadvantages are organ rejection and animal infections. Liver transplantation from animals is getting more advanced. Should animal organs be farmed for human transplants? Yes they should if problems are solved. Xenotransplantation: weighing individual benefit and risks is currently difficult for patients. Because animal donor organs are only a temporary measure in human transplantation. Liver transplantation from animals can help more patients now than before.