Liquid biopsy in colorectal cancer. Precision diagnosis and treatment. 8-2

Liquid biopsy in colon cancer or rectal cancer allow monitoring of treatment in real time. What is liquid biopsy? How it can help guide chemotherapy selection for colorectal cancer patients? How tumor changes behavior under chemotherapy?

There is a lot of experience with using automated molecular analyzers for liquid biopsy in colorectal cancer. Dr. Anton Titov, MD. Colon cancer DNA and RNA in peripheral blood of patients can be rapidly analyzed every four weeks by liquid biopsy. By doing liquid biopsy we see the tumor load. Prof. Dr. Hans-Joachim Schmoll, MD. We measure colon cancer genetic material in patient’s blood by automated molecular analyzers. We can also see the changes of the molecular biology of the tumor under chemotherapy treatment. Tumor changes after 1st-line treatment or experimental therapy. Dr. Anton Titov, MD. Liquid biopsy can show us tumor molecular changes. it is a new method – to monitor tumor molecular tumor profile regularly during treatment. It is a model for many cancers to start monitoring from early treatment. you monitor the tumor response to chemotherapy in real time by liquid biopsy. Prof. Dr. Hans-Joachim Schmoll, MD. Correct. Tumor response will be monitored by the X-rays, the MRI and so on. But liquid biopsy allows more precise monitoring than regular biopsy. It is difficult to stick the patient in the liver all the time to biopsy metastatic colon cancer tumor. We can monitor tumor just by doing liquid biopsy. technology is there. It is a question of economics. Liquid biopsy monitoring of colon cancer tumor is part of very expensive international project on colon cancer. The project is running now. Prof. Dr. Hans-Joachim Schmoll, MD. We are very excited about liquid biopsy. Dr. Anton Titov, MD. It is a new method to discover new colon cancer treatments. Liquid biopsy in personalized therapy selection & monitoring helps to observe changes in colon cancer tumor under treatment. Liquid Biopsy that detects and monitors cancer in high-risk patients with stage 4 metastatic and advanced colorectal cancer. colon cancer biopsy results can predict the next chemotherapy combination in colon cancer treatment. Liquid biopsy can show the changes of the molecular biology of the tumor under chemotherapy treatment. Leading colorectal cancer expert discusses tumor monitoring by liquid biopsy.