Individual cancer risk DNA testing becomes common. Cancer genetic tests are moving into mainstream medicine. Rare cancer mutations are not so rare.
Transcript of video
Do rare mutations affect you? Angelina Jolie cancer risks. BRCA gene mutations increase risk for breast cancer, colon cancer, prostate cancer, ovarian cancer, and uterine cancer. BRCA1 gene testing is required if any relative has these cancers. Dr. Anton Titov, MD. Active management of personal genetic risks by actress Angelina Jolie. Top Genetics and Precision Medicine expert explains. Why it’s important to be aware of genetic risks for cancer. Everyone can carry individual genetic mutations that increase risk of cancer and autoimmune disease. Video interview with top expert in medical genetics and genetic DNA ancestry. Medical second opinion confirms that ovarian cancer diagnosis is correct and complete. Medical second opinion ensures that genetic DNA ancestry information is included in diagnosis of ovarian cancer. Dr. Anton Titov, MD. Medical second opinion also helps to choose the best personalized treatment strategy for ovarian cancer. Seek medical second opinion on ovarian cancer and be confident that your precision medicine treatment is the best. Individual cancer risk genetic testing. Medical Second Opinion. It was reported around the world. Angelina Jolie underwent radical bilateral mastectomy. She removed her ovaries and fallopian tubes. She learned that she inherited a certain BRCA cancer gene mutation. She had family history of breast and ovarian cancers. Her mother died at the young age from ovarian cancer. Dr. Anton Titov, MD. One of her relatives died from breast cancer at a relatively young age. Such cancer risk mutations occur in 1% to 2% one to two percent of population. Cancer risk mutations are relatively recent mutations. Some of your work indicates this. Dr. Esteban Gonzalez Burchard. Yes. Medical Second Opinion. Please talk about clinically relevant cancer mutations in the genome? Dr. Anton Titov, MD. Why genetic DNA ancestry tests are important for personalized medicine? Medical Second Opinion. Dr. Esteban G. Gonzalez, MD. Professor of Pharmacogenomics, UCSF. Angelina Jolie is a perfect example of being proactive. Unfortunately her mother died from ovarian cancer. Angelina Jolie got some insights into the genetic nature of her cancer risks. She actually made a very bold statement for the world. Because normally what people get cancer they tend be embarrassed about about it. They hide it. She did something really good for medicine and herself. It was good for public health in the public perspective. Angelina Jolie knew she was at risk for colon cancer, breast cancer, uterine cancer. But also everyone of her descendants, all her relatives were at risk for prostate cancer too. So I tell all patients that I see. You may have someone who has colon cancer or prostate cancer. Then get BRCA tested. Even in prostate cancer I tell them to get tested. This is a male only disease. I tell them to get tested as well. Because BRCA mutation is a risk factor for prostate cancer. It is not just a risk factor, it is a very strong risk factor for prostate cancer. Several points were important about Angelina Jolie BRCA testing. Dr. Harry Oster in New York and Dr. Bob Nussbaum here at UCSF did the research work on BRCA mutations. But BRCA gene was patented by Myriad Genetics. So Dr. Oster and Dr. Nussbaum won the lawsuit in the Supreme Court of the United States. The court overthrew the BRCA patent. So now everybody can get BRCA genetic test for free. BRCA test is now cheap. My sister-in-law had breast cancer. she happens to be Asian. I demanded that they test her for BRCA gene. The first response was negative. NO, because it’s only a European disease. We won’t pay for it. Dr. Esteban G. Gonzalez, MD. I said this. No, I understand genetics. I understand DNA ancestry. She happens to be Filipina. They have European DNA ancestry in them. Using that argument we were able to get her BRCA mutation tested under the insurance. Medical Second Opinion. Dr. Anton Titov, MD. That’s again the implications of DNA ancestry at each individual gene. It includes the genes that carry mutations with specific cancer or other diseases. Medical Second Opinion. Dr. Esteban G. Gonzalez, MD. Yes, yes. Individual cancer risk genetic testing. Actor Angelina Jolie as example of how to act sometimes serious genetic health risks are found. BRCA mutations and cancer.