Alzheimer's disease vaccine. This is a very interesting question. Because Alzheimer's disease treatment remains the holy grail of dementia research and treatment. You have worked on potentially vaccinating against Alzheimer's disease. You worked on vaccination against Multiple sclerosis. What could you tell about the potential for the vaccines to work against neurodegenerative and autoimmune diseases? Dr. Anton Titov, MD. Dr. Howard Weiner, MD. We are doing work in Alzheimer's disease now. Dr. Howard Weiner, MD. We published data on vaccination against dementia. Dr. Howard Weiner, MD. We are going to hopefully do some clinical trials for a nasal vaccine for Alzheimer's disease. Vaccine helps to remove the a-beta from the brain. Dr. Howard Weiner, MD. We are actively working on vaccine therapy for Alzheimer’s disease. How far along is that work on Alzheimer's disease vaccine? Dr. Anton Titov, MD. What is the potential? Dr. Anton Titov, MD. Would patients need to be immunized before the Alzheimer's disease starts? Dr. Anton Titov, MD. Or when the first symptoms based on some genetic tests. It is very difficult to predict when Alzheimer’s disease starts. Or once patients already show the clinical signs of Alzheimer’s? Dr. Anton Titov, MD. The earlier you treat any disease the better is the result of treatment. Many of the Alzheimer's disease clinical trials are taking patients who are cognitively normal and treating them. The nasal vaccine we are talking about would work best in preclinical stage of Alzheimer’s disease. You would screen patients who are normal now. But they are beginning to have Alzheimer's disease. That you could measure by imaging. It is interesting. In London Dr. Howard Weiner, MD. I spoke to the glaucoma and neurodegenerative disease expert. They are identifying in retinal cells the signs of degeneration 10 to 20 years before patients might show the first symptoms of Alzheimer's disease. The first clinical symptoms. Maybe combining that with the vaccination. Absolutely, it is possible. Alzheimers disease treatment at early stages with vaccine to prevent neurodegeneration is becoming a reality. Leading immunology expert.