{"product_id":"why-gut-recovery-after-colon-surgery-differs-the-role-of-an-overactive-rectosigmoid-brake","title":"Why Gut Recovery After Colon Surgery Differs: The Role of an Overactive Rectosigmoid “Brake”","description":"\u003cp\u003eA new perspective from researchers at the University of Auckland proposes that slower recovery of gut function after right-sided colon surgery (right hemicolectomy) compared to left-sided surgery may be caused by an overactive “brake” in the lowest part of the colon, called the rectosigmoid region. This hyperactivity involves abnormal cyclic muscle contractions called cyclic motor patterns (CMPs) that can persist for at least 16 hours after surgery. If confirmed, this insight could lead to personalized recovery plans and new treatments for prolonged post-operative ileus (PPOI), a condition that affects one in five colorectal surgery patients and increases hospital costs by 70%.\u003c\/p\u003e\n\n\u003ch1\u003eWhy Gut Recovery After Colon Surgery Differs: The Role of an Overactive Rectosigmoid “Brake”\u003c\/h1\u003e\n\n\u003ch2 id=\"toc\"\u003eTable of Contents\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"#ddn-key-points\"\u003eKey Points\u003c\/a\u003e\u003c\/li\u003e\n\n  \u003cli\u003e\u003ca href=\"#background\"\u003eBackground: Why This Research Matters\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"#gut-recovery\"\u003eHow Gut Recovery Differs Between Right and Left Colectomy\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"#mechanisms\"\u003eUnderstanding Ileus: What Goes Wrong After Surgery\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"#colonic-physiology\"\u003eNew Insights into Colon Motility\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"#testing\"\u003eTesting the Hypothesis: How Researchers Plan to Confirm This\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"#implications\"\u003eImplications for Future Care\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"#conclusion\"\u003eConclusion\u003c\/a\u003e\u003c\/li\u003e\n  \u003cli\u003e\u003ca href=\"#ddn-faq\"\u003eFrequently Asked Questions\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"#source\"\u003eSource Information\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003c!-- ddn:keypoints:start --\u003e\n\u003ch2 id=\"ddn-key-points\"\u003eKey Points\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eProlonged post-operative ileus affects one in five colorectal surgery patients and raises hospital costs by 70%.\u003c\/li\u003e\n\u003cli\u003eA hypothesis proposes that right-sided colectomy recovers slower due to overactive cyclic motor patterns in the rectosigmoid region.\u003c\/li\u003e\n\u003cli\u003eA study in 8 patients found intense rectosigmoid hyperactivity lasting at least 16 hours after right colectomy, active 94% of the time.\u003c\/li\u003e\n\u003cli\u003eThe normal post-meal 'rectosigmoid brake' may become pathologically hyperactive after right colon surgery, acting as a functional obstruction.\u003c\/li\u003e\n\u003cli\u003eElectrocolonography, a non-invasive technique, could someday help confirm this hypothesis and personalize recovery care.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c!-- ddn:keypoints:end --\u003e\n\n\n\u003ch2 id=\"background\"\u003eBackground: Why This Research Matters\u003c\/h2\u003e\n\u003cp\u003eBowel surgery is known to disrupt colonic function, both in the short term and over the long term. One in five patients undergoing colorectal surgery experiences a delayed return of colonic function lasting more than 3 days. This condition is called \u003cstrong\u003eprolonged post-operative ileus (PPOI)\u003c\/strong\u003e. Ileus means that the bowel temporarily stops working normally. PPOI is not just a nuisance—it raises the cost of care by \u003cstrong\u003e70%\u003c\/strong\u003e due to longer hospital stays, additional tests, and complications such as blood clots and the need for intravenous nutrition (parenteral nutrition).\u003c\/p\u003e\n\u003cp\u003eModern recovery protocols, known as \u003cstrong\u003eenhanced recovery after surgery (ERAS)\u003c\/strong\u003e, have reduced hospital stay length, complications, and PPOI rates. However, it remains difficult to know which specific parts of these protocols help most. Most importantly, the actual mechanisms that cause the gut to slow down after surgery are still incompletely understood.\u003c\/p\u003e\n\u003cp\u003eThe authors of this perspective article focus on one striking finding: right-sided colon resections recover more slowly than left-sided ones. They propose a new explanation: after right colectomy, the distal (lower) colon becomes abnormally hyperactive, creating a functional obstruction that delays recovery. This idea is based on recent high-resolution manometry studies that detected intense bursts of rhythmic muscle activity in the rectosigmoid area after surgery.\u003c\/p\u003e\n\n\u003ch2 id=\"gut-recovery\"\u003eHow Gut Recovery Differs Between Right and Left Colectomy\u003c\/h2\u003e\n\u003cp\u003eTo measure gut recovery, researchers often use a composite measure called \u003cstrong\u003eGI-2\u003c\/strong\u003e: the time until a patient can tolerate an oral diet and passes their first bowel motion. GI-2 correlates well with overall bowel transit. The authors note that an important distinction exists between ordinary ileus (post-operative ileus, POI) and prolonged post-operative ileus (PPOI). According to a 2013 consensus definition, POI is an “obligatory” delay that resolves within 4 days. If gut function is still not recovered by day 4, it is called PPOI—an abnormally prolonged course. “Primary” PPOI arises directly from surgery, while “secondary” PPOI follows complications, especially sepsis. Left-sided resections have a higher rate of severe post-operative sepsis, which can affect recovery times, and this must be accounted for when comparing outcomes.\u003c\/p\u003e\n\u003cp\u003eWith these caveats, a substantial body of evidence shows that \u003cstrong\u003eright-sided colectomies recover more slowly than left-sided ones\u003c\/strong\u003e in modern colorectal practice. Key studies include:\u003c\/p\u003e\n\u003cul\u003e\n  \u003cli\u003eA 2016 Swiss study: right-sided resections had a \u003cstrong\u003ethreefold higher rate of ileus\u003c\/strong\u003e (24% vs. 8%, P = 0.002) and longer hospital stays (6 vs. 5 days, P = 0.02), with equivalent ERAS compliance.\u003c\/li\u003e\n  \u003cli\u003eA 2017 study using the American College of Surgeons NSQIP database: right colectomy with ileocolic anastomosis was formally recognized as a risk factor for ileus, with a \u003cstrong\u003erisk ratio (RR) of 1.218 (P = 0.003)\u003c\/strong\u003e compared to other partial colectomies. In contrast, “partial colectomy with low pelvic anastomosis” did not increase ileus risk (RR 0.992, P = 0.91).\u003c\/li\u003e\n  \u003cli\u003eA 2019 study using the same NSQIP database, comparing nearly \u003cstrong\u003e13,000 patients\u003c\/strong\u003e undergoing elective oncological resections: right colectomy had a higher incidence of primary PPOI (\u003cstrong\u003e11.5% vs. 8.8%, P \u0026lt; 0.001\u003c\/strong\u003e). This study used coarsened-exact-matching to adjust for age, sex, ASA score, operative approach, and transfusion rates.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSeveral potential explanations were previously offered for this difference, including differential activation of retroperitoneal nerves, anastomosis technique (handsewn ileocolic vs. stapled colo-colic\/colorectal), and whether the ileocolic anastomosis was constructed in an iso- or anti-peristaltic direction. However, the authors propose an alternative mechanism: the intact distal colon may be physiologically responsible due to hyperactive cyclic motor patterns.\u003c\/p\u003e\n\n\u003ch2 id=\"mechanisms\"\u003eUnderstanding Ileus: What Goes Wrong After Surgery\u003c\/h2\u003e\n\u003cp\u003ePreventing ileus has become a major goal because improving patient outcomes and reducing hospital costs go hand in hand. The expected hospital stay after bowel surgery has dropped from a traditional 10+ days to just 3–5 days or less, thanks to minimally invasive surgery and ERAS. Yet PPOI still occurs in \u003cstrong\u003e10–25%\u003c\/strong\u003e of patients in published settings.\u003c\/p\u003e\n\u003cp\u003eNormal gut recovery proceeds in phases: the small bowel usually recovers within 24 hours, the stomach within 24–48 hours, and the colon is the slowest, taking more than 48 hours. If a patient has not reached GI-2 by day 4, a consensus panel suggested diagnosing PPOI when \u003cstrong\u003etwo of the following five criteria\u003c\/strong\u003e are present:\u003c\/p\u003e\n\u003col\u003e\n  \u003cli\u003eNausea or vomiting over the preceding 12 hours.\u003c\/li\u003e\n  \u003cli\u003eInability to tolerate a solid or semi-solid diet over the two preceding meal times.\u003c\/li\u003e\n  \u003cli\u003eAbsence of flatus and stool over the last 24 hours.\u003c\/li\u003e\n  \u003cli\u003eAbdominal distension.\u003c\/li\u003e\n  \u003cli\u003eRadiological confirmation of ileus on plain X-ray or CT within the last 24 hours.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eOnce PPOI is recognized, treatment is mainly supportive: nasogastric tube placement, intravenous fluids, and parenteral nutrition if needed. Secondary causes such as intra-abdominal sepsis or anastomotic leak must be excluded, and electrolyte imbalances corrected. PPOI is the most common cause of acute intestinal failure requiring parenteral nutrition, adding substantially to healthcare costs.\u003c\/p\u003e\n\u003cp\u003eIleus development is complex. The autonomic nervous system (ANS) plays a central role, both directly and through inflammation. Key triggers include surgical breaches of the peritoneum (lining of the abdominal cavity). Other risk factors include \u003cstrong\u003eopen surgery, wounds longer than 10 cm, extensive bowel handling, difficult surgery, red blood cell transfusion, and male sex\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eTraditionally, two phases of ileus were described: an early neurogenic phase (excessive inhibitory spinal reflexes) followed by a longer inflammatory phase. More recently, a \u003cstrong\u003echolinergic anti-inflammatory pathway\u003c\/strong\u003e was discovered, showing a second, larger influence of the autonomic nervous system. The inflammatory phase begins when tissue injury activates immune cells such as mast cells and macrophages, which release inflammatory chemicals (TNFα, interleukins) that suppress muscle contractions throughout the bowel.\u003c\/p\u003e\n\u003cp\u003eImbalance between the sympathetic (“fight-or-flight”) and parasympathetic (“rest-and-digest”) branches of the ANS is now well accepted as a cause of colonic dysfunction. Importantly, the ANS also acts high up in the inflammatory cascade. Intra-operative electrical stimulation of the vagus nerve has shown potential to reduce both inflammatory cytokines and the occurrence of PPOI.\u003c\/p\u003e\n\u003cp\u003eOne example of the ANS’s dual role is \u003cstrong\u003eneuroaxial blockade (NAB)\u003c\/strong\u003e, such as epidural analgesia. Post-operative epidurals were historically used in ERAS. Pain, anxiety, and peritoneal irritation activate inhibitory sympathetic reflexes that block the release of acetylcholine, the main neurotransmitter for peristalsis. Epidurals can interrupt these reflexes. A 2016 Cochrane review found faster gastrointestinal recovery with epidural analgesia for open surgery. A more recent meta-analysis of eight randomized studies (three laparoscopic) demonstrated faster gut recovery with epidurals compared to opioid patient-controlled analgesia. However, epidurals are now used less often because of the rise of minimally invasive surgery. In short, ANS imbalance is likely a key influence in ileus, and this role is extended in the new proposal for right hemicolectomy recovery.\u003c\/p\u003e\n\n\u003ch2 id=\"colonic-physiology\"\u003eNew Insights into Colon Motility\u003c\/h2\u003e\n\u003cp\u003eEarly manometry studies—which measure pressure waves inside the colon—used only a small number of sensors and focused on \u003cstrong\u003ehigh-amplitude propagating sequences (HAPS)\u003c\/strong\u003e: large waves that travel antegrade (forward) over long distances and are responsible for mass movements. In the past decade, \u003cstrong\u003ehigh-resolution manometry (HRM)\u003c\/strong\u003e has revealed additional, shorter, lower-amplitude waves that occur both antegrade and retrograde (backward), many times per minute. These are called \u003cstrong\u003ecyclic motor patterns (CMPs)\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eCMPs are thought to arise from \u003cstrong\u003einterstitial cells of Cajal\u003c\/strong\u003e (the colon’s pacemaker cells), but they require co-regulation from the enteric and autonomic nervous systems and integration by smooth muscle. In laboratory experiments, artificial electrical stimulation could regulate CMP amplitude, frequency, and even direction of propagation. There are currently no established large-animal models to study CMPs in the context of surgery. A systematic review found 19 studies on colonic electromechanical abnormalities underlying post-operative ileus, but most were low-resolution, and two animal studies from the 1970s and 80s failed to detect colonic CMPs.\u003c\/p\u003e\n\u003cp\u003eThe most important recent finding came from a high-resolution manometry study in \u003cstrong\u003e8 right colectomy\/ileocolic resection patients\u003c\/strong\u003e. Contrary to the traditional view that colonic motor activity becomes quiet after surgery, the rectosigmoid region showed \u003cstrong\u003eintense and sustained hyperactivity of CMPs\u003c\/strong\u003e, lasting for at least 16 hours post-operatively. The patterns were active \u003cstrong\u003e94% of the study duration\u003c\/strong\u003e in all eight patients. The pathophysiology remains unclear, but the researchers proposed that excessive sympathetic nerve activity after surgery could inhibit enteric nerves that are themselves inhibitory, thereby allowing hyperactive CMPs to be expressed without restraint. This mechanism is still speculative—other neural or hormonal factors may also contribute.\u003c\/p\u003e\n\u003cp\u003eAnother key observation was that CMP activity increased as the time to enter surgery approached, even in patients who were fasted and pain-free. The researchers suggested that pre-operative anxiety, acting through sympathetic nervous output, could explain this rise. In a normal post-prandial (after-meal) state, the rectosigmoid demonstrates a specialized \u003cstrong\u003e“rectosigmoid brake”\u003c\/strong\u003e: retrograde CMPs appear after meals at a rate of \u003cstrong\u003e2–4 cycles per minute\u003c\/strong\u003e, limiting rectal filling and helping maintain continence. In one study, the number of retrograde contractions at the rectosigmoid increased dramatically after a 700 kcal meal: from 3.9 ± 3.8 pre-prandial to 84.9 ± 26.0 post-prandial (P \u0026lt; 0.05), with active contractions occupying 27% of the study duration.\u003c\/p\u003e\n\u003cp\u003eThe authors propose that after right colectomy, this normal brake becomes pathologically hyperactive, acting as a \u003cstrong\u003efunctional obstruction\u003c\/strong\u003e that prevents stool from moving forward. In left-sided resections (including anterior resection), the regions responsible for the hyperactivity are surgically removed, which may explain why gut recovery is faster. This concept is summarized visually in the original Figure 1B.\u003c\/p\u003e\n\n\u003ch2 id=\"testing\"\u003eTesting the Hypothesis: How Researchers Plan to Confirm This\u003c\/h2\u003e\n\u003cp\u003eTo test this hypothesis, researchers would need to observe colonic hyperactivity throughout the entire period of colonic recovery—not just the first 16 hours. Traditional high-resolution manometry (HRM) is difficult for patients to tolerate for more than 24 hours, especially when early mobilization is encouraged in ERAS protocols. There is also an inherent risk of using anorectal instrumentation after left-sided resections with an anastomosis. Nevertheless, longer-duration HRM studies following right colectomies are currently ongoing.\u003c\/p\u003e\n\u003cp\u003eAn emerging technology called \u003cstrong\u003eelectrocolonography (EColG)\u003c\/strong\u003e could solve these problems. EColG uses a high-resolution electrode array placed on the body surface to detect colonic electrical activity non-invasively. It has been specifically validated to detect the same 2–4 cycles per minute CMPs, including the increased post-prandial activity. If EColG is validated in post-operative patients, it could be used to compare right vs. left colectomy in detail, with a much greater patient comfort.\u003c\/p\u003e\n\u003cp\u003eThe researchers’ unit is currently recording simultaneous HRM and body surface recordings with meal tests in non-operative participants to further validate EColG. In right colectomy patients, EColG would be expected to show varying durations of rectosigmoid hyperactivity. For left-sided resections, depending on how much of the rectosigmoid junction is removed, reduced activity would be anticipated—consistent with findings in patients with chronic Low Anterior Resection Syndrome (a condition where the rectum’s normal function is disrupted after rectal cancer surgery).\u003c\/p\u003e\n\n\u003ch2 id=\"implications\"\u003eImplications for Future Care\u003c\/h2\u003e\n\u003cp\u003eIf the link between rectosigmoid hyperactivity and PPOI is confirmed, it would challenge one current paradigm in ileus pathophysiology. Better blockade of somatic and autonomic pain pathways to reduce sympathetic output could be beneficial. Perhaps more importantly, a \u003cstrong\u003enon-invasive biomarker of colonic recovery\u003c\/strong\u003e would enable clinicians to identify “at risk” patients early and to personalize ERAS protocols according to the side and extent of resection.\u003c\/p\u003e\n\u003cp\u003eAt present, most ERAS protocols are non-specific—they do not account for the location of the resection or individual patient factors. A better understanding of how different anatomical regions of the colon behave after surgery could personalize peri-operative expectations and treatments. For example, patients whose rectosigmoid hyperactivity has settled but whose bowels have not yet opened might be safely discharged earlier, based on objective data rather than waiting for traditional milestones.\u003c\/p\u003e\n\u003cp\u003eThe authors also note that many treatments for PPOI have been tested without clear reference to the underlying mechanisms. Having a reliable biomarker could help researchers test new therapies that specifically modulate CMP hyperactivity. It could also help delineate positive and negative factors that affect the duration of ileus.\u003c\/p\u003e\n\n\u003ch2 id=\"conclusion\"\u003eConclusion\u003c\/h2\u003e\n\u003cp\u003eIn conclusion, early emerging evidence suggests that post-operative rectosigmoid cyclic motor pattern hyperactivity could hinder the return of gut function and explain why recovery after right colectomy is slower than after left colectomy. This is still a hypothesis that requires more data. The researchers are currently working on non-invasive techniques to test it directly in patients. If proven, this paradigm could lead to a shift toward personalized, measurement-based care for colorectal surgery patients, improving outcomes and reducing the burden of prolonged ileus.\u003c\/p\u003e\n\n\u003c!-- ddn:faq:start --\u003e\n\u003ch2 id=\"ddn-faq\"\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eWhat is prolonged post-operative ileus (PPOI)?\u003c\/h3\u003e\n\u003cp\u003ePPOI is a delayed return of colonic function lasting more than 3 days after bowel surgery. It affects about one in five colorectal surgery patients. Diagnosis requires two of five criteria by day 4: nausea or vomiting, inability to tolerate solid food, no flatus or stool for 24 hours, abdominal distension, or radiological confirmation of ileus.\u003c\/p\u003e\n\u003ch3\u003eWhat are cyclic motor patterns (CMPs)?\u003c\/h3\u003e\n\u003cp\u003eCMPs are short, low-amplitude waves in the colon that occur many times per minute, moving forward or backward. They are thought to arise from pacemaker cells called interstitial cells of Cajal, with regulation from the nervous system. High-resolution manometry has revealed these patterns, which may play a role in post-operative recovery.\u003c\/p\u003e\n\u003ch3\u003eWhat evidence links rectosigmoid hyperactivity to slower gut recovery?\u003c\/h3\u003e\n\u003cp\u003eA high-resolution manometry study in 8 patients who had right colectomy or ileocolic resection found intense, sustained hyperactivity of cyclic motor patterns in the rectosigmoid region. These patterns were active 94% of the study time and lasted at least 16 hours after surgery, contrasting with the traditional view that colonic activity becomes quiet.\u003c\/p\u003e\n\u003ch3\u003eWhat is the 'rectosigmoid brake' and how might it become overactive?\u003c\/h3\u003e\n\u003cp\u003eNormally, after a meal, the rectosigmoid region produces retrograde contractions at 2-4 cycles per minute, which limit rectal filling and help maintain continence. After right colectomy, researchers suggest this brake becomes pathologically hyperactive, creating a functional obstruction that delays stool movement and gut recovery.\u003c\/p\u003e\n\u003ch3\u003eHow could this hypothesis be tested in patients more comfortably?\u003c\/h3\u003e\n\u003cp\u003eElectrocolonography (EColG) uses a non-invasive electrode array on the body surface to detect the same 2-4 cycles per minute patterns. If validated after surgery, it could compare right versus left colectomy recovery with greater patient comfort than traditional high-resolution manometry, which is difficult to tolerate for more than 24 hours.\u003c\/p\u003e\n\u003ch3\u003eCould this research lead to personalized recovery plans?\u003c\/h3\u003e\n\u003cp\u003eIf confirmed, a non-invasive biomarker of colonic recovery could help identify at-risk patients early and tailor enhanced recovery protocols based on the side and extent of resection. For example, patients with settled rectosigmoid hyperactivity might be safely discharged earlier, based on objective data rather than waiting for traditional milestones.\u003c\/p\u003e\n\u003ch3\u003eShould I seek a second opinion if my bowel function is slow to return after right-sided colon surgery?\u003c\/h3\u003e\n\u003cp\u003eIf your bowel function has not returned by postoperative day 4 after a right-sided colectomy, you may have prolonged post-operative ileus (PPOI), a condition affecting one in five colorectal surgery patients. Recovery from right-sided colon surgery is slower on average than left-sided, and recent research suggests an overactive 'brake' in the rectosigmoid colon may be responsible. A second opinion can help verify your diagnosis and ensure your recovery plan accounts for this new understanding. Diagnostic Detectives Network provides independent expert second opinions.\u003c\/p\u003e\n\u003c!-- ddn:faq:end --\u003e\n\n\u003ch2 id=\"source\"\u003eSource Information\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eOriginal article title:\u003c\/strong\u003e Variable Gut Function Recovery After Right vs. Left Colectomy May Be Due to Rectosigmoid Hyperactivity\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors:\u003c\/strong\u003e Sean Ho Beom Seo, Ian Bissett, and Gregory O’Grady\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eJournal:\u003c\/strong\u003e Frontiers in Physiology, Volume 12, Article 635167\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePublication date:\u003c\/strong\u003e 23 February 2021\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDOI:\u003c\/strong\u003e 10.3389\/fphys.2021.635167\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding:\u003c\/strong\u003e The authors were supported by the Colorectal Surgical Society of Australia and New Zealand, the Royal Australasian College of Surgeons, the John Mitchell Crouch Fellowship, and the New Zealand Health Research Council.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThis patient-friendly article is based on peer-reviewed research. It has been rewritten to explain the original findings in everyday language while preserving all key data. The original article is a perspective piece, which means it presents a hypothesis and supporting arguments, not a completed clinical trial. For any personal medical decisions, please consult your healthcare provider.\u003c\/em\u003e\u003c\/p\u003e","brand":"DiagnosticDetectives.Com","offers":[{"title":"Default Title","offer_id":47471117926556,"sku":null,"price":0.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/diagnosticdetectives.com\/ar\/products\/why-gut-recovery-after-colon-surgery-differs-the-role-of-an-overactive-rectosigmoid-brake","provider":"DiagnosticDetectives.Com","version":"1.0","type":"link"}